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Children aged 412 years were diagnosed with ASD according to DSM criteria, both boys and girls were included, and the study explicitly excluded participants with major psychiatric comorbidities such as ADHD, depressions, bipolar disorder, anxiety disorders, epilepsy, severe intellectual disabilities, or recent antipsychotic use, ensuring relative homogeneous sample focused on irritability

El artculo advierte adems sobre una limitacin metodolgica: la mayora de los estudios se basa en autoinforme sin cuestionarios validados, lo que dificulta comparar frmacos y estimar con precisin la magnitud del problema